Abstract
For
many years, various medicinal plants have been used for the treatment of
different neuropsychological diseases, like anxiety and depression behaviors.
In the present study, the effects of Scrophularia striata extract on anxiety and
depression behaviors were
investigated in
adult male mice. Methods:
In this study 12 groups (n=7) of adult male mice weighing 25-30g were used.
In first protocol 6 groups of mice were received saline and extract of Scrophularia
striata (10, 50, 100, 160 and 220 mg/kg) for 14 consecutive days and then
tested in elevated plus maze. The second protocol was as the same but at the
end of the injections depression was assessed with forced swimming test. Results:
Our findings showed that S. striata significantly (p<0.01) reduced
anxiety at two doses of 100 and 160 mg/kg as well as attenuated depression at
160 mg/kg (p<0.01) in the EPM and FST tests, respectively