Pharm Sci. 2017;23(3): 238-243.
doi: 10.15171/PS.2017.35

Scopus ID: 85032004891
  Abstract View: 1202
  PDF Download: 1002

Research Article

Bioactive Properties of Eremostachys macrophylla Montbr. & Auch. Rhizomes Growing in Iran

Parina Asgharian 1,2, Abbas Delazar 1,2, Farzaneh Lotfipour 2, Solmaz Asnaashari 3*

1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.


Background: The current study was assigned to evaluate the antioxidant, general toxicity, anti-proliferative and antimicrobial activities of different extracts obtained from rhizomes of Eremostachys macrophylla (Lamiaceae). Methods: All activities were evaluated by obtaining extracts of E. macrophylla in n-hexane, DCM (dichloromethane) and MeOH (methanol) by soxhlet apparatus. The antioxidant activity of the extracts was evaluated in terms of FRST (free radical scavenging activity test) by DPPH (2, 2-diphenyl-1-picrylhydrazyl). BSLT (Brine shrimp lethality tests), MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay and disc diffusion method were carried out to determine the general toxicity, anti-proliferative and antibacterial activities of the different extracts, respectively. Results: The findings of the study for antioxidant, anti-proliferative and antibacterial effects showed that DCM extract was the most active fraction, but n-hexane extract indicated the most potent effect against Artemia salina. Conclusion: The results revealed strong bioactive effects of nonpolar fractions of E. macrophylla rhizomes. Thus, it is possible to suggest some new potential antioxidant, cytotoxic and antibacterial agents with no harmful effects on noncancerous cells.
Keywords: Eremostachys macrophylla, Antioxidant, General toxicity, Antiproliferative, Antibacterial
First Name
Last Name
Email Address
Security code

Abstract View: 1201

Your browser does not support the canvas element.

PDF Download: 1002

Your browser does not support the canvas element.

Submitted: 26 Nov 2016
Accepted: 04 Jan 2017
ePublished: 30 Sep 2017
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)