Alireza Jalali, Younes Panahi, Fariborz Sadeghi Shahrestani, Masoud Saghafinia, Alireza Saadat, Amirhossein Sahebkar*
Abstract
Background:
Post-operative nausea and vomiting (PONV) is commonly experienced by patients
after surgical procedures.
Objectives:
The purpose of the present trial was to compare the antiemetic efficacy of
three drugs (generic granisetron, metoclopramide and kytril) for the prevention
of acute emesis induced by eye surgery.
Patients
and Methods: One hundred and fifty-one patients undergoing
ophthalmic surgery were randomized to receive generic granisetron (n = 51), metoclopramide
(n = 50) or kytril (n = 50), intravenously. A standard general anaesthetic
technique and postoperative analgesia was used. The PONV and adverse effects of
study drugs were assessed during the early (0-6 hrs) and late (6-24 hrs) periods
after administration of medications.
Results:
There was no significant difference between the groups regarding demographic
characteristics. Complete protection from retching and vomiting was achieved in
all patients receiving generic granisetron. Incidence of nausea, retching and
vomiting was significantly higher in the metoclopramide group when compared with
generic granisetron group. The most common adverse event in the three groups
was headache. No significant difference in the incidence of adverse effects
attributable to the study drug was observed between the groups.
Conclusions:
Generic granisetron was found to have favourable efficacy in the prevention of PONV
after eye surgery and could be regarded as a safe and inexpensive alternative
for kytril and metoclopramide.