Effects of Green Tea on Serum Iron Parameters and Antioxidant Status in Patients with β–Thalassemia Major

Abstract

Background: Iron overload and accelerated oxidative stress are main factors in the pathogenesis of β–thalassemia major. The objectives of this study were to examine the effects of green tea consumption on serum iron, ferritin and transferrin saturation (TS) and antioxidant status in β–thalassemia patients. Methods: This study conducted on 52 subjects with β–thalassemia major (males and females) ≥18 y. The intervention group (n= 26) consumed green tea (2.5 g /150 mL hot water) 3 times per day for 8 wk and  the control group (n= 26) followed a water regimen. Anthropometric measurements, blood samples and 24-h dietary recalls were gathered at the baseline and at the end of the trial. Independent t test, paired t test and analysis of covariance were used for data analysis. Results: Mean of serum iron, ferritin, malondialdehyde (MDA) and total antioxidant capacity (TAC) were 234.7±49.3 μg/dL, 2776.07±533.4 ng/dl, 3.01±0.64 nmol/ml and 2.2665±0.77 nmol/l in green tea group and 298.19±66.87 μg/dL, 3070.23±643.6 ng/dl, 298.19±66.87 nmol/ml and 2.0862 ±0.35 nmol/l in control group at baseline, respectively. Green tea significantly decreased serum levels of iron, ferritin and MDA and increased TAC compared with control group (all, P < 0.05). No significant changes were seen in TS value in both groups. Conclusions: Green tea consumption had favorable effects on iron status and oxidative stress in studied subjects and may be useful in management of these risk factors in patients with β–thalassemia major.

Keywords: β–thalassemia major, Green tea, Iron parameters, Anti-oxidant status