Ahmad Ghanbari
1, Yashar Sarbaz
1, Vahid Jouyban-Gharamaleki
2,3, Karim Jouyban-Gharamaleki
4, Jafar Soleymani
5, Abolghasem Jouyban
2,6*1 Department of Mechatronic Engineering, Faculty of Engineering Emerging Technologies, University of Tabriz, Tabriz, Iran
2 Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Mechatronic Engineering, International Campus, University of Tabriz, Tabriz, Iran
4 Tabriz Technical Training Center No. 2, Tabriz, Iran
5 Drug Applied Research Center, Tabriz University of Medical of Sciences, Tabriz, Iran
6 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Background: Solubility of a
drug/drug candidate is an essential information in the pharmaceutical area.
Classical solubility determination method used in the laboratories are
expensive and time-consuming. Attempts were made to provide an automated
solubility determination setup based on a laser monitoring technique.
Methods: In a previously
developed setup, drug powder was added to a given quantity of the solvent which
made some troubles in practical applications. The present work reports another
setup which adds solvent to a given mass of the drug. The validity of the
measured solubilities is checked by comparing the measured solubilities of
acetaminophen at two temperatures in water and ethanol mixtures with the
corresponding data from the literature.
Results: The results reveal
that the improved setup could overcome the limitations of the previously
developed setup and could be used for drug solubility determination.
Conclusion: The improved setup
overcomes the troubles made in the previous setup and could be used in
generating large amount of solubility data to be used in the pharmaceutical
industry.