Abstract
Background: After
abdominal surgery, postoperative adhesion is a serious problem that threats the
patients. The Present study evaluated the protective effects of morphine on
abdominal adhesion in an experimental model in rat. Materials: An
experimental intraabdominal adhesion model was created in 24 adult male rats by
ischemic bottom method. The animals were divided into three groups. The control
group was not treated by morphin. In the
morphine group, the animals received morphine as 10 mg/kg once a day for three
days after surgery. In group 3, the addicted animals to morphine received
morphine as 10 mg/kg daily after surgery. Drug dependency was confirmed by
naloxone. Adhesions were evaluated by nair and swollon scoring system 10 days
after surgery. Results: There was a significant differences
regard to the length (P<.05), thickness (P<.05), and severity of
adhesions (P<.05) among the control, morphine, and morphine-addicted groups.
Conclusion: Morphine reduced the severity of postoperative
adhesions the present study. Morphine could affect postoperation adhesion
through suppression of inflammation. It is suggested that opioid receptor(s)
might involve in this process. Therefore,
selective ligands could be used and offer a pharmacologic strategy in
preventing adhesion formation.