Pharm Sci. 2019;25(2):165-170.
doi: 10.15171/PS.2019.24
  Abstract View: 22
  PDF Download: 18

Short Communication

Further Analysis on Solubility Measurement and Thermodynamic Modeling of Benzoic Acid in Monosolvents and Binary Mixtures

Abolghasem Jouyban 1,2 ORCiD, Elaheh Rahimpour 3, William Acree 4 * ORCiD

1 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Chemistry, University of North Texas, Denton, TX 76203-5070, USA.

Abstract

Background: Recently Sandeepa et al. reported the solubility of benzoic acid in six monosolvents (i.e. tributyl phosphate, diacetone alcohol, methyl-n-propyl ketone, methyl acetate, amyl acetate, and isooctane) and five binary systems (i.e. ethanol + hexane, isopropyl alcohol + hexane and chloroform + hexane, acetone + hexane, and acetone + water) along with some numerical analyses. The reported calculations have been reanalyzed and some recommendations and further computations were proposed. Methods: Further analyses were performed based on combined nearly ideal binary solvent/Redlich-Kister, the modified Wilson model, general single model, Jouyban–Acree model and Jouyban–Acree–van’t Hoff model. Results: The mentioned numerical analyses were used to predict the solubility of benzoic acid in the binary solvent mixtures at various temperatures and the predicted solubility data were compared with their corresponding experimental values by calculating relative deviations. Conclusion: The investigated models provide good estimation of the solubility behavior of benzoic acid in the binary solvent mixtures at various temperatures.
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Submitted: 25 Nov 2018
Accepted: 18 Dec 2018
First published online: 30 Jun 2019
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